Are you living with pain and decreased function from osteoarthritis of the knee?

If so, you may be eligible to participate in the ACTiVION-I clinical research study.

Criteria

To qualify, participants must:

  • Be male or female aged 40 years or older

  • Have no clinically relevant abnormalities on physical examination or clinical laboratory testing (hematology, coagulation, chemistry, urinalysis) per Investigator

    1. Have no history of significant organ system disorders.
    2. Have body mass index (BMI) between 18.5 and 40.0.
    3. Have systolic blood pressure 90 to 160 mmHg, and diastolic blood pressure 50 to 95 mmHg.
  • Have Grade 2 or 3 primary OA of the target knee, as determined by the radiographic criteria of Kellgren and Lawrence

  • Have a score ≥ 40 on the 100 mm 0-10 Medical Pain Scale for pain for the target knee

  • Provide written informed consent after the nature of the study is fully explained and understood by the subject

  • Use an effective method of birth control during the first 24 months of the study. Because the study product has unknown risks to pregnant women, embryos, fetuses (unborn babies), and nursing infants, both male and female subjects enrolled in this trial must take appropriate precautions to reduce the risk of pregnancy.  Sterilization (male/Female or postmenopausal status okay.

The study doctor or staff will discuss additional requirements with you.

About PRO

Physicians’ Research Options (PRO) is an experienced Clinical Research Company dedicated to the performance of Phase II, III and IV Pharmaceutical and Pilot/Pivotal Medical Device clinical trials. Our staff experience totals over 60 years in Clinical / Medical Research.

Our staff recruits for and manages studies in Utah, Nevada, and Colorado.

Call us or fill out the form below to inquire about participating.

Draper, UT Office: (801) 352-9228

    Osteoarthritis (OA) is the most common form of arthritis. It is a disease that affects all the tissues of the joint, including the cartilage, bone, ligaments, and muscles. It can develop in any number of joints, but most commonly affects the knees, hands, and hips. The symptoms of OA can vary in severity, but in its more severe forms OA is apainful condition that restricts mobility, interrupts sleep, and interferes with the sufferer’s enjoyment of life. OA is considered a chronic (long-lasting) disease and other than joint replacement surgery there is presently no cure.